Retrospective Analysis of Risk Factors for Length of Stay in Intensive Care Unit and Survival Outcome from Premature Infants with Premature Rupture of Membranes

Cong YE, Jun-Rong WANG, Ming-Hui FAN, Yu-Bo HU


Objective: To analysis of risk factors for length of stay in intensive care unit and
survival outcome from premature infants with premature rupture of membranes (PROM). Methods: A retrospective study including 189 singleton pregnant women with PPROM at 28– 34 gestational weeks was conducted. Gestational age at delivery, route of delivery, oligohydramnios, maternal age and maternal complications including gestational diabetes, preeclampsia and chorioamnionitis, newborn birth weight, gender, premature retinopathy (ROP), necrotizing enterocolitis (NEC), sepsis, fetal growth retardation (FGR), intracranial
hemorrhage (ICH), bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS), primary pulmonary hypertension (PPH), congenital cardiac disease (CCD), patent ductus arteriosus (PDA) and use of betamethasone were used to predict neonatal outcomes in terms of length of stay in the ICU and survival. Results: The preeclampsia, low birth weight, ROP, CCD, BPD, and PDA were significant confounders for length of stay in the ICU. Among them, low birth weight was the most powerful confounder for prolongation of the ICU stay
(P<0.001). In multivariate logistic regression analyses, oligohydramnios (AFI≤ 5 cm), low birth weight, PDA, ROP were significantly correlated with neonatal survival. Low birth weight was the most powerful confounder in neonatal survival (P=0.001). Conclusion: Premature deliveries should be avoided to prevent infection and to prolong the latent period in cases of PROM in order to decrease prematurity related outcomes.


Premature rupture of membranes, Neonate, ICU, Survival, Retrospective analysis


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