Clinical Study of Low Dose Urokinase Combined with Low Molecular Weight Heparin in the Treatment of Deep Venous Thrombosis of the Lower Extremities

Jian YIN, Rui-Si XU, Si-Qi ZHANG

Abstract


To observe the curative effect of slow infusion of low-dose urokinase and low
molecular weight heparin calcium in elderly patients with acute deep venous thrombosis. Methods: 45 patients with acute deep venous thrombosis in the lower extremities were selected and randomly divided into two groups. 20 cases of the control group using the traditional method of administration by the limbs of other body superficial vein infusion of small dose urokinase (400000uꞏtimes-1,1timeꞏd -1) thrombolysis and low molecular weight heparin (100uꞏkg-1, Ih, 1timeꞏ12 h-1) on the first day of anticoagulation. Play with warfarin 2.5
mg - late 1 (adjusted according to INR dosage, INR 2~3) for 14 days; 25 patients in the experimental group improved drugs were given by the distal limb superficial vein slow pump into the small dose of urokinase (100000uꞏtimes-1, 2timesꞏd-1), low molecular weight heparin calcium (100 Uꞏkg-1, Ih, 1timeꞏ12 h-1), the first day with warfarin 2.5 mg - late 1 (adjusted according to INR dosage, INR 2~3) for 14 days. Results: in the control group, 2 cases were
cured, 7 cases were improved, 11 cases were invalid, 9 cases were total effective, 11 cases were cured in the experimental group, 9 cases were improved, 5 cases were invalid, 20 cases were total effective. The total effective rate of the two groups was statistically different (P = 0.03). Conclusion: the improved method of slow infusion of small dose of urokinase and low molecular heparin calcium through the distal superficial veins of the affected limb in elderly patients with deep venous thrombosis is superior to the traditional medication.


Keywords


Deep venous thrombosis, Urokinase, Curative effect


DOI
10.12783/dtbh/icmsb2018/25428

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