Incidence and Risk Factors of Peripherally Inserted Central Catheter-related Venous Thrombosis in Lung Cancer Patients

Lian-Kui HAN, Gang XU, Chuan XU, Bo LIU, Di LIU


Background: Peripherally inserted central catheter (PICC) is widely used in patients with cancer. PICC-related venous thrombosis is one of the most severe complications, but the risk factors are not well defined. We analyzed the incidence and risk factors causing PICC-related venous thrombosis in patients with lung cancer. Methods: A retrospective study was conducted in Guizhou Provincial People's hospital from January 2012 to December 2015. All lung cancer patients who met inclusion criteria were included. The influences of sex, age, limb, puncture vein, platelet count, prothrombin time (PT), and fibrinogen (FIB) on the incidence of venous thrombosis were analyzed. Univariable analysis was performed using χ2 detection, and multivariate analysis was carried out using Logistic regression analysis. Results: In total, 1972 patients with 49 cases of PICC-related venous thrombosis were enrolled. The average time interval from PICC placement to thrombosis forming was 15.77 ± 7.62 days. Univariable analysis showed that gender, indwelling limb, indwelling vein, and FIB value had significant influence on the incidence of PICC-related venous thrombosis (P < 0.05). Furthermore, logistic regression model analysis revealed that gender (P = 0.027, 95% CI = 1.320-4.275), indwelling vein (P = 0.012, 95% CI = 1.331-3.046), and FIB value (P = 0.031, 95% CI = 1.605-3.663) were associated with the incidence of PICC-related venous thrombosis. Conclusion: Gender, indwelling vein, and FIB are risk factors for PICC-related venous thrombosis.


Lung Cancer, Peripherally Inserted Central Catheters, Venous Thrombosis, Risk Factor


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