Imaging Prediction of the Prognosis in Carbon Monoxide Poisoning Encephalopathy: Magnetic Resonance Imaging Study



In order to explore the evaluation value of diffusion kurtosis imaging (DKI) on the prognosis of patients with carbon monoxide toxic encephalopathy, we analyzing the characteristics of early MRI and DKI images of patients with carbon monoxide poisoning encephalopathy. 19 patients with clinically confirmed acute carbon monoxide poisoning encephalopathy (5.2±1.25 days after poisoning) and 10 age-matched normal volunteers underwent routine MRI scan, of which 5 patients received DKI and MRI scan 3 weeks to 3 months after poisoning. The DKI parameters included fractionalapatipy (FA), mean diffusion (MD) and mean kurtosis (MK) were analyzed in different brain area between the case group and the normal control group. During the acute phase of carbon monoxide poisoning, MRI scans showed abnormal signal in bilateral frontal and temporal lobe cortex, subcortical white matter area and hippocampus, while bilateral cerebral white matter region and globus pallidus were showed in the patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP). Two of the five patients were diagnosed with DECAMP, their early MK value was increased, while the early FA value of each lesion was decreased and MD value was increased in the globus pallidus during follow-up. The change of MK value might be correlated with the prognosis of lesions. Abnormal increase of MK value in early lesions may indicate poor prognosis.


Carbon monoxide poisoning encephalopathy, MRI, Diffusion kurtosis imaging, Delayed encephalopathy after acute carbon monoxide poisoning.Text


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