The Effects of Sufentanil Postconditioning on Ischemic-reperfusion Injury in Rats

Li-fang LIU, Guo-qing ZHAO, Ming GAO, Yan ZHANG, Kai LI

Abstract


This study aims to explore the protective effects of sufentanil-postconditioning on myocardial cells in rats. Methods: Choosing 80 healthy rats, all was established in Myocardial Ischemia-reperfusion Model. Dividing them into 8group(n=10):1)SHAM group;2)CONgroup;3)IPC group; 4~8) SUF group. Observe and count:① The Amount of Apoptosis Positive Cell Nucleus, Total Cell Nucleus, and rate of myocardial cell apoptosis. ②Concentration of cTnI. ③Weight of Left Ventricle, Weight of Ischemic Myocardium, Weight of infarction. The areas of myocardial ischemia and myocardial infarction are also calculated. ④HE staining. Results:① The apoptosis index is significantly lower in SHAM Group than others groups (P0.05). ④For HE staining, the myocardium tissue of rats in SHAM Group shows no obvious pathological change. But the change is visible in CON group. IPC Group and SUF group with mild pathological change. Conclusion: Post-treatment with sufentanil alleviates myocardial ischemia-reperfusion injury in rats.

Keywords


Sufentanil, Apoptosis, Myocardial infarction, Postconditioning, Ischemia reperfusion


DOI
10.12783/dtmse/amsee2017/14298

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