A General Overview of Detection Methods for Single Nucleotide Polymorphism

Hai YANG

Abstract


Single nucleotide polymorphism, often abbreviated to SNP, in the genomes of species individuals refers to a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population. In recent years, the research of detection algorithm for SNP has been a hotspot in genomics, computational biology and informatics. Most of SNP detection algorithms are based on sequencing technology of the next generation sequencing (NGS). In this paper, a general overview of detection methods for single nucleotide polymorphism is made to deeply analyze several current mainstream detection algorithms for SNP. It is important for further development of this field of bioinformatics.

Keywords


Single Nucleotide Polymorphism, Next Generation Sequencing, HMM, MAQ


DOI
10.12783/dtcse/msota2018/27582

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